Trius is working with Lawrence Livermore National Laboratories (LLNL) to develop a new class of antibacterial agents that target the bacterial cell wall enzyme MurB. This program is funded by a contract from the Defense Threat Reduction Agency (DTRA) through the research stage, subject to the achievement of certain milestones. In this program, Trius and LLNL apply structure-based drug discovery technologies to design novel antibacterial agents with spectrum on important commercial and biodefense Gram-negative pathogens.
Using the FAST technology, Trius has shown that inhibition of MurB leads to synergy with beta-lactam antibiotics and in particular with cephalosporins. Consequently, MurB-based antibacterial agents might lead to commercially important combination drugs.